Volume 2, Issue 2 (2021)
Sanchez DJ*, Casillas P, Nguyen NV
Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, USA
- *Corresponding Author:
- Sanchez DJ
Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, USA.
Tel: 19094698479; E-mail: email@example.com
Received date: August 11, 2021; Accepted date: August 26, 2021; Published date: August 31, 2021
Citation: Sanchez DJ, Casillas P, Nguyen NV. Stimulation of IL-16 Release by Cells Exposed to HIV Virion Proteins. J Clin Microbiol Immunol. 2021;2(2):35-41.
Copyright: © 2021 Sanchez DJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: The pathogenesis and immune response to chronic viral infection are multifaceted especially for HIV infection. The effect of HIV on the systemic immune environment of the infected individual is profound and triggered by multiple stimuli. While replication-competent viral infection induces a large spectrum of immune responses, such as cytokine release, we focused on what happens when cells are exposed to replication-incompetent virions and their components.
Results: Monitoring the cytokines released from T cell lines exposed to HIV virion components, we found several cytokines were upregulated with IL-16 being the most upregulated. HIV virion components induced Caspase-3 activation which is required for IL-16 release and this IL-16 release is dependent on protein components within the HIV virion.
Conclusion: Overall, this work allows us to see that replication-incompetent HIV virions have an impact on the immune landscape of a person infected by HIV. We see that exposure of T cells to HIV virion proteins leads to Caspase-3 activation and subsequent IL-16 release.
HIV; AIDS; Innate Immunity; Cytokines, Cytokine; Array; IL-16; Caspase-3.