Journal of Virology and Infectious Diseases

Volume 2, Issue 1 (2021)

Research Article - Open Access
Liver Fibrosis by Transient Elastography Among HIV/HBV and HBVMono Infected Patients on Long-Term Tenofovir Therapy in Jos, Nigeria

Mary Duguru1, Anejo-okopi Joseph2,3,*, Davwar P Mark1, Omaiye Patientce1, Audu Onyemocho4, Onwuamah Chika5, Okojokwu Julius Ocheme2, Bulus Jonathan6, Chima Anyuku Azubuike George7, Akpa Samuel Tanko2,3, Ramyil M. Selju Crown8, Fiyaktu Bwotle Yakubu9, Agaba Patricia10, Agbaji oche1,3, Sagay Solomon Atiene3,11, Hawkins Claudia12, Okeke N. Edith1

1Department of Medicine, University of Jos, and Jos University Teaching Hospital, Jos, Nigeria

2Department of Microbiology, University of Jos, Hospital, Jos, Nigeria.

3HIV Care and Treatment Center, Jos University Teaching Hospital, Jos, Nigeria

4Department of Epidemiology and Community Health, Benue State University, Makurdi, Nigeria

5Human Virology laboratory, Microbiology department, Nigerian Institute of Medical Research, Yaba, Lagos

6Department of Family Medicine, Plateau State Specialist Hospital, Jos, Nigeria

7Department of Family Medicine, Bingham University and HIV/AIDS Program, Bingham University Teaching Hospital, Jos

8Department of Medical Microbiology and Parasitology, Bingham University Teaching Hospital, Jos, Nigeria

9Department of Chemical Pathology, Jos University Teaching Hospital, Jos, Nigeria

10Department of Family Medicine, University of Jos, Jos, Nigeria

11Department of Obstetrics and Gynecology, University of Jos, Jos, Nigeria

12Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA

*Corresponding Author:
Anejo-okopi Joseph BSC, MBA, MSC, PhD
Department of Microbiology, University of Jos, Main Campus Bauchi Road, Jos, Nigeria.
Tel: +2348061584647
E-mail: josephokopi@yahoo.com, okopijoseph@gmail.com

Received date: May 13, 2021; Accepted date: May 24, 2021; Published date: May 31, 2021

Citation: Duguru M, Joseph A, Mark DP, Patientce O, Onyemocho A, Chika O, et al. Liver Fibrosis by Transient Elastography Among HIV/HBV and HBV-Mono Infected Patients on Long-Term Tenofovir Therapy in Jos, Nigeria. J Virol Infect Dis. 2021;2(1):18-25.

Copyright: © 2021 Duguru M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Chronic Hepatitis B (CHB) infection both in HIV coinfection and HBV-mono infection are associated with risk of progression to chronic liver disease. Combined tenofovir cART and mono-tenofovir have improved survival in CHB patients. There is paucity of data on Transient Elastography (TE) in HIV/ HBV and HBV-mono infected patients. We aimed to assess liver fibrosis using transient elastography in relation to liver function biomarkers and HBV DNA among HIV/HBV and HBV-mono infected patients on long-term antiviral therapy.

Methods: A cross-sectional study in HBV-HIV and HBV-mono infected adults patients receiving a tenofovir-containing antiretroviral and mono-tenofovir ≥12months at four selected tertiary hospitals in Jos Metropolis from February 2018 to May 2019, after obtained ethical approval from the IRBs and informed consents. The patients’ HBV DNA, platelet count, hematological, biochemical parameters were assessed and liver stiffness measured by TE in kilopascals (kPa), and valid TE measurements were interpreted as: normal (F0-1 0-4), minimal fibrosis (F2 5-7.4), moderate (F3 7.5.9.4), severe fibrosis and cirrhosis (F4 ≥9.5).

Results: A total of 101 (50 HIV/HBV and 51 HBV-mono infected) were enrolled during the study period, comprising of 42.6% males and 57.4% females. The median age interquartile range (IQR); among the HIV/HBV was 40.5(36.0-45.3) and HBV-mono infected 41.0(35.0-49.0). The median Platelet count was low in HBV-mono 195 (168-257), p 0.034. The overall prevalence of severe liver ?brosis (≥ 9.5kPa) was 13/101(13.0%), and among HIV/HBV coinfected and HBV-mono infected patients was 4/50 (8.0%) and 9/51 (17.6%) respectively. The plasma HBV-DNA was <20 copies/mL in 38/50 (76.0%) HIV/HBV and in 30/51(58.8%) HBV-mono patients, 10/50(20.0%) HIV/HBV and 19/50 (37.3%) HBV-mono patients had plasma HBV-DNA of 20-20000 copies/mL. The prevalence of Severe fibrosis (≥ 9.5): in HIV/HBV was 4(8.0%), HBV-mono 9(17.6%). The overall prevalence of thrombocytopenia was 4/101(3.9%): HIV/HBV 1(2.0%) and HBV-mono 3(5.9%).

Keywords

Liver fibrosis; Transient Elastography; Tenofovir; Chronic Hepatitis B virus; Nigeria



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