Archives of Immunology and Immunotherapy

Volume 1, Issue 1 (2020)

Review Article - Open Access
Infiltrating Treg Cells Suppress Anti-Tumor Immunity in Tumor Microenvironment

Tania Sarkar, Gaurisankar Sa*

Division of Molecular Medicine, Bose Institute, P-1/12, CIT Road, Scheme VIIM, Kolkata, WB, 700054, India

*Corresponding Author:
Gaurisankar Sa
Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata-700054, India.
Tel: +91-33-2569-3258 Fax: +91-33-2355-3886 E-mail: gauri@jcbose.ac.in

Received date: November 30, 2020; Accepted date: December 17, 2020; Published date: December 24, 2020

Citation: Sarkar T (2020) Infiltrating Treg Cells Suppress Anti-Tumor Immunity in Tumor Microenvironment. Arch Immuno Immunother. 2020;1(1): 1-11.

Copyright: © 2020 Sarkar T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Avoidance of immune-surveillance by tumor is one of the important hallmarks of cancer and tumor microenvironment adapts host immune system in favor of this immune-escape mechanism. One of the major immune components that is responsible for immune-escape of tumor is T-regulatory cell. Tregs are found to be elevated in the peripheral circulation of tumor patient and from the circulation they infiltrate to the tumor-site which depends on the interaction between chemokines and chemokine receptors. Infiltrated Tregs are potent immunosuppressors and foster tumor growth by suppressing the effectiveness of helper T cells, NK cells, dendritic cells and macrophages making a tolerogenic microenvironment in the tumorsite. Rapid regeneration of infiltrating Tregs in the tumor milieu aids to this process. Combined action of suppression and survival of tumor infiltrating Tregs in tumor microenvironment makes them a major stumbling block in the battle against cancer.

Keywords

Treg cells; Tumor microenvironment; Inhibit antitumor immune; Anti-tumor